Confined placental mosaicism in short term culture
نویسندگان
چکیده
منابع مشابه
Confined placental mosaicism.
In most pregnancies the chromosomal complement detected in the fetus is also present in the placenta. The detection of an identical chromosomal complement in both the fetus and its placenta has always been expected as both develop from the same zygote. However, in approximately 2% of viable pregnancies studied by chorionic villus sampling (CVS) at 9 to 11 weeks of gestation, the cytogenetic abn...
متن کاملConfined placental mosaicism and intrauterine fetal growth.
Fetal growth is a complex and dynamic process regulated by a large number of interactive factors of fetal, maternal, and placental origin. As a result, any abnormality of fetal growth has a complex multifactorial pathogenesis. It has been estimated that about 50% of intrauterine fetal growth is determined by fetal genes. Maternal disease, her nutritional intake and behaviours, such as smoking, ...
متن کاملDetection of cell free placental DNA in maternal plasma: direct evidence from three cases of confined placental mosaicism.
F etal cells are consistently found in the maternal circulation, and polymerase chain reaction based studies have led to the identification of cell free fetal DNA (fetal DNA) in maternal blood. Approximately 1.2 nucleated fetal cells/ml of whole blood from women carrying a male fetus were detectable, and relative enrichment of fetal DNA was detected in the maternal plasma and serum. The amount ...
متن کاملComment on 'confined placental mosaicism: implications for fetal chromosomal analysis using microarray comparative genomic hybridization'.
NE Thames Regional Genetics Service, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK TDL Genetics, The Doctors Laboratory, London, UK UCL Institute of Child Health, London, UK University College Hospital NHS Foundation Trust, London, UK Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK *Correspondence to: Lyn S. Chitty. E-mail: [email protected]...
متن کاملNormal newborn with prenatal suspicion of X chromosome monosomy due to confined placental mosaicism.
The recent introduction of cell-free DNA (cfDNA)-based noninvasive prenatal testing (NIPT) offers pregnant women a more accurate method than traditional serum screening methods for detecting fetal aneuploidies. Clinical trials have demonstrated the efficacy of NIPT for Down, Edwards and Patau syndromes. However NIPT approaches that take advantage of single-nucelotide polymorphism (SNP) informat...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: ABI Genetika
سال: 2016
ISSN: 0534-0012,1820-6069
DOI: 10.2298/gensr1603955p